Journal: PLOS Computational Biology
Article Title: Coarse-grained model of serial dilution dynamics in synthetic human gut microbiome
doi: 10.1371/journal.pcbi.1013222
Figure Lengend Snippet: A hierarchically clustered heatmap of the ratio (on log 10 scale) between perturbed and unperturbed strain abundances at steady state in response to a 100-fold increase in the concentration of a single metabolite in the mega media. Columns and rows represent 38 metabolites (or their clusters) and 63 strains in the synthetic gut community, respectively. Three representative clusters of strains have been enclosed in boxes for easy identification. 10 strains marked with a black arrow were classified as poorly responsive to metabolite addition and were therefore excluded from the in silico experiment to equalize the strain abundances in .
Article Snippet: For example, the following 10 strains marked with a black arrow in were perturbed by fewer than 3 metabolites: Bacteroides caccae DSM 43185, Marvinbryantia formatexigens DSM 14469, Bacteroides coprophilus DSM 18228, Clostridium leptum DSM 753, Ruminococcus bromii ATCC 8503, Parabacteroides johnsonii DSM 18315, Lactococcus lactis DSMZ 20729, Lactobacillus ruminis ATCC 25644, Tyzzerella nexilis DSM 2243, and Catenibacterium mitsuokai DSM 15897.
Techniques: Concentration Assay, In Silico